Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50020228
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628003(CHEMBL5427670)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628004(CHEMBL5416002)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628005(CHEMBL5397239)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628006(CHEMBL5400478)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628002(CHEMBL5424780)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628002(CHEMBL5424780)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628004(CHEMBL5416002)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628003(CHEMBL5427670)
Affinity DataIC50: 5nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628007(CHEMBL5421788)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in pyroptosis preincubated with compound for 3 hrs followed by nigericin stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628006(CHEMBL5400478)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628005(CHEMBL5397239)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50628007(CHEMBL5421788)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as reduction in IL-1beta release preincubated with compound for 3 hrs followed by nigericin stimula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed