Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50019400
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 5.90nMAssay Description:Binding affinity to mGluR2 (unknown origin) FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 9.83E+3nMAssay Description:Binding affinity to mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 1.90E+4nMAssay Description:Binding affinity to mGluR3 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 2.67E+4nMAssay Description:Binding affinity to mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR5 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR4 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to mGluR1 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618878(CHEMBL5405921)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213143(US9278960, 8-50 | US9636337, 8-50)
Affinity DataKi:  0.460nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618874(CHEMBL5409898)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618881(CHEMBL5418895)
Affinity DataKi:  0.740nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618876(CHEMBL5429000)
Affinity DataKi:  0.780nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618875(CHEMBL5394450)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618871(CHEMBL5435246)
Affinity DataKi:  0.960nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618873(CHEMBL5429261)
Affinity DataKi:  1nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618870(CHEMBL5436775)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213109(US9278960, 8-16 | US9636337, 8-16)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213108(US9278960, 8-15 | US9636337, 8-15)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618879(CHEMBL5405655)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618880(CHEMBL5410262)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213112(US9278960, 8-19 | US9636337, 8-19)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618877(CHEMBL5429002)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213058(US9278960, 6-5 | US9636337, 6-5)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618869(CHEMBL5425858)
Affinity DataKi:  7nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50618872(CHEMBL5399050)
Affinity DataKi:  13nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213105(US9278960, 8-12 | US9636337, 8-12)
Affinity DataKi:  15nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213107(US9278960, 8-14 | US9636337, 8-14)
Affinity DataKi:  19nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM213056(US9278960, 6-3 | US9663506, Example 6-3)
Affinity DataKi:  40nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataKi:  2.26E+3nMAssay Description:Binding affinity to guinea pig adenosine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed