Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50020187
TargetSerine/threonine-protein kinase B-raf(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627152(CHEMBL5434139)
Affinity DataEC50:  493nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627154(CHEMBL5434427)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50561575(CHEMBL4758840)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627156(CHEMBL5430816)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50504106(CHEMBL4462946)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627153(CHEMBL5434941)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627153(CHEMBL5434941)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627153(CHEMBL5434941)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627153(CHEMBL5434941)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627157(CHEMBL5405262)
Affinity DataIC50: 17nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627163(CHEMBL5395764)
Affinity DataIC50: 20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50504106(CHEMBL4462946)
Affinity DataIC50: 20nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50625428(CHEMBL5412271)
Affinity DataIC50: 22nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 23nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM636322(US20230365546, Compound 105)
Affinity DataIC50: 35nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 45nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627147(CHEMBL5430224)
Affinity DataIC50: 49nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627148(CHEMBL5427031)
Affinity DataIC50: 65nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50625426(CHEMBL5401353)
Affinity DataIC50: 67nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM174917(US9096593, P-1646)
Affinity DataIC50: 100nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM174917(US9096593, P-1646)
Affinity DataIC50: 100nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627146(CHEMBL5438972)
Affinity DataIC50: 463nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627158(CHEMBL5431607)
Affinity DataIC50: 500nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627160(CHEMBL5437567)
Affinity DataIC50: 590nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627150(CHEMBL5427763)
Affinity DataIC50: 764nMAssay Description:Inhibition of FLT3 D835Y (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627159(CHEMBL5407349)
Affinity DataIC50: 930nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627161(CHEMBL5426809)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627149(CHEMBL5427440)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of FLT3 D835Y (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627150(CHEMBL5427763)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of wildtype FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627149(CHEMBL5427440)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627162(CHEMBL5413174)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627142(CHEMBL5398821)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627143(CHEMBL5440643)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627144(CHEMBL5412823)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627145(CHEMBL5397512)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627149(CHEMBL5427440)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627151(CHEMBL5439288)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to nucleotide Y5 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627155(CHEMBL5436195)
Affinity DataKi:  47nMAssay Description:Binding affinity to adenosine receptor A1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
Insilico Medicine Hong Kong

Curated by ChEMBL
LigandPNGBDBM50627155(CHEMBL5436195)
Affinity DataKi:  895nMAssay Description:Binding affinity to adenosine receptor A2a (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed