Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50020177
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 2nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 17nMAssay Description:Negative allosteric modulator activity at human wildtype KGA using glutamine as substrate preincubated for 1 hr followed by substrate addition in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627115(CHEMBL5395264)
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627118(CHEMBL5440854)
Affinity DataIC50: 400nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627116(CHEMBL5397149)
Affinity DataIC50: 400nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627115(CHEMBL5395264)
Affinity DataIC50: 500nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627120(CHEMBL5416840)
Affinity DataIC50: 540nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627116(CHEMBL5397149)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627118(CHEMBL5440854)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627120(CHEMBL5416840)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627119(CHEMBL5429695)
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627118(CHEMBL5440854)
Affinity DataIC50: 2.10E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA using glutamine as substrate preincubated for 1 hr followed by substrate addition in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627119(CHEMBL5429695)
Affinity DataIC50: 2.10E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627115(CHEMBL5395264)
Affinity DataIC50: 2.20E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA using glutamine as substrate preincubated for 1 hr followed by substrate addition in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627112(CHEMBL5429363)
Affinity DataIC50: 3.00E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627110(CHEMBL5411097)
Affinity DataIC50: 3.00E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627114(CHEMBL5419380)
Affinity DataIC50: 3.60E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627114(CHEMBL5419380)
Affinity DataIC50: 3.70E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627110(CHEMBL5411097)
Affinity DataIC50: 4.00E+3nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627112(CHEMBL5429363)
Affinity DataIC50: 4.00E+3nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627121(CHEMBL5427281)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627122(CHEMBL5430605)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627117(CHEMBL5407538)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627108(CHEMBL5426005)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627123(CHEMBL5401983)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627113(CHEMBL5422979)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627111(CHEMBL5423195)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627109(CHEMBL5418186)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627107(CHEMBL5406556)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627123(CHEMBL5401983)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627122(CHEMBL5430605)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627121(CHEMBL5427281)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627117(CHEMBL5407538)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627113(CHEMBL5422979)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627111(CHEMBL5423195)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627109(CHEMBL5418186)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627107(CHEMBL5406556)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50627108(CHEMBL5426005)
Affinity DataIC50: 1.30E+4nMAssay Description:Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as substrate preincubated for 20 mins followed by substrate addition in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed