Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50019555
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620120(BAVDEGALUTAMIDE | Bavdegalutamide | Arv-110 | ARV-...)
Affinity DataEC50:  3.60nMAssay Description:Induction of androgen receptor degradation in human VCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataEC50:  0.600nMAssay Description:Induction of androgen receptor degradation in human VCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620120(BAVDEGALUTAMIDE | Bavdegalutamide | Arv-110 | ARV-...)
Affinity DataEC50:  5.5nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataEC50:  0.600nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620469(CHEMBL5399353)
Affinity DataIC50: 78nMAssay Description:Displacement of Fluormone AL Green from androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620468(CHEMBL5421324)
Affinity DataIC50: 800nMAssay Description:Displacement of Fluormone AL Green from androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataIC50: 800nMAssay Description:Displacement of Fluormone AL Green from androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620467(CHEMBL5432214)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of Fluormone AL Green from androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620466(CHEMBL5393933)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of Fluormone AL Green from androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using methionine as substrate preincubated for 5 mins followed by NADPH addition and measured after 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed