Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50018860
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  56nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to recombinant MERTK (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 24(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  120nMAssay Description:Binding affinity to recombinant MST3 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant CDK2 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 15(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to recombinant MAPK15 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMAP/microtubule affinity-regulating kinase 4(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to recombinant MARK4 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMAP/microtubule affinity-regulating kinase 3(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to recombinant MARK3 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant FLT1 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to recombinant BMPR2 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBMP-2-inducible protein kinase(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant BMP2K (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  4.30nMAssay Description:Binding affinity to recombinant GSK3B (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50602057(CHEMBL1908842 | JNJ-28312141)
Affinity DataKd:  310nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  570nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataKd:  324nMAssay Description:Inhibition of ALK5 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataKd:  84nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataKd:  186nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50: 36nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 68nMAssay Description:Inhibition of ALK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 74nMAssay Description:Inhibition of BMPR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 95nMAssay Description:Inhibition of ALK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 235nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613308(CHEMBL5271220)
Affinity DataIC50: 461nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50: 506nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: 630nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed