Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50019371
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  40nMAssay Description:Binding affinity to Rac1 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by fluorescence anisotropy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50234661(CHEMBL1619630 | CHEBI:76227)
Affinity DataEC50:  2.12E+5nMAssay Description:Inhibition of Rac1 in human HeLa cells pretreated for 1 hr followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50234661(CHEMBL1619630 | CHEBI:76227)
Affinity DataEC50:  9.60E+4nMAssay Description:Inhibition of CDC42 in human HeLa cells pretreated for 1 hr followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataEC50:  1.07E+3nMAssay Description:Inhibition of CDC42 in human HeLa cells pretreated for 2 hrs followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataEC50:  574nMAssay Description:Inhibition of Rac1 in human HeLa cells pretreated for 2 hrs followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of GST-tagged wildtype Cdc42 (unknown origin) incubated for 2 hrs in presence of BODIPY FL GDP by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM43220(MLS000693334 | 4-[3-(4-methoxyphenyl)-5-phenyl-3,4...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of GST-tagged wildtype Cdc42 (unknown origin) incubated for 2 hrs in presence of BODIPY FL GTP by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618635(CHEMBL4303199)
Affinity DataKd:  332nMAssay Description:Binding affinity to fluorescently labeled Cdc42 (unknown origin) assessed as dissociation constant by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618634(CHEMBL4303380)
Affinity DataKd:  1.14E+4nMAssay Description:Binding affinity to CM-5 sensor chip immobilized Cdc42 (unknown origin) assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618634(CHEMBL4303380)
Affinity DataKd:  6.40E+3nMAssay Description:Binding affinity to Cdc42 (unknown origin) assessed as dissociation constant by fluorescence titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 3(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  230nMAssay Description:Binding affinity to Rac3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 2(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  60nMAssay Description:Binding affinity to Rac2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  50nMAssay Description:Binding affinity to Rac1b (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCell division control protein 42 homolog(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50: 78nMAssay Description:Inhibition of Cdc42 P21-binding domain in human MDA-MB-231 cells incubated for 24 hrs by pulldown assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 3(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50: 103nMAssay Description:Inhibition of Rac1/Rac2/Rac3 P21-binding domain in human MDA-MB-231 cells incubated for 24 hrs by pulldown assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells incubated for 24 hrs by pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618633(CHEMBL5436670)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of GTP-tagged recombinant Rac1 (unknown origin) PAK binding domain expressed in HEK293T cells by pull- down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTransforming protein RhoA(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618636(CHEMBL2153773)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human RHoA (1 to 181 residues) expressed Escherichia coli BL21 (DE3) cells assessed as GDP/GTP exchange rate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRho-related GTP-binding protein RhoC(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM22164(CI 981 | CHEMBL1487 | (3R,5R)-7-[2-(4-fluorophenyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of RhoC geranylgeranylation in human UMSCC1 cells by G-LISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed