Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50019353
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618433(CHEMBL5437573)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618434(CHEMBL5394366)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618435(CHEMBL5403163)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618434(CHEMBL5394366)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618433(CHEMBL5437573)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114631((1E)-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-on...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114608((1E)-1-(3,4-dichlorophenyl)propan-1-one thiosemica...)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114645((1E)-1-(3-trifluoromethyl-phenyl)propan-1-one thio...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114653((1E)-1-(3,4-dichlorophenyl)ethan-1-one thiosemicar...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114644((1E)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-one...)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114651((1E)-1-(3-bromophenyl)ethan-1-one thiosemicarbazon...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114649((1E)-1-[3-(trifluoromethyl)phenyl]ethan-1-one thio...)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50618435(CHEMBL5403163)
Affinity DataIC50: 175nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-FR-AMC as substrate preincubated for 20 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114613((1E)-1-(3-bromophenyl)propan-1-one thiosemicarbazo...)
Affinity DataIC50: 176nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114626(3,5-bis(trifluoromethyl)benzaldehyde thiosemicarba...)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114648(3,4-dichlorobenzaldehyde thiosemicarbazone | CHEMB...)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114639(3-(trifluoromethyl)benzaldehyde thiosemicarbazone ...)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114607(3,5-dichlorobenzaldehyde thiosemicarbazone | CHEMB...)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50114665(2-(trifluoromethyl)benzaldehyde thiosemicarbazone ...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50148049((1E)-1-(1,1'-biphenyl-4-yl)ethan-1-one thiosemicar...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50148053((1E)-1-(1,1'-biphenyl-3-yl)ethan-1-one thiosemicar...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50148050((1E)-1-(4-phenoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed