Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50020682
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50280579(CHEMBL4169930)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human SOS1 mediated nucleotide exchange in presence of BODIPY-GDP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632666(CHEMBL5429481)
Affinity DataEC50:  2.90E+3nMAssay Description:Activation of human SOS1 mediated nucleotide exchange in presence of BODIPY-GDP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632667(CHEMBL5414348)
Affinity DataEC50:  1.04E+4nMAssay Description:Activation of human SOS1 mediated nucleotide exchange in presence of BODIPY-GDP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of SOS1/KRAS (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657341(6,7-dimethoxy-2-methyl-N-[(1R)-1-(naphthalen-1-yl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human His-tagged SOS1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657521(US20240083857, Example 200 | US20240083857, Exampl...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human His-tagged SOS1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human His-tagged SOS1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 580nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of SOS1/KRAS (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632669(CHEMBL5437533)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SOS1 CD (564 to 1049 residues) (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM58490(SMR000466355 | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of SOS1 CD (564 to 1049 residues) (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632670(CHEMBL5432547)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of SOS1 CD (564 to 1049 residues) (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632671(CHEMBL4530195)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of SOS1 (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632672(CHEMBL1988909)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of SOS1 (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657341(6,7-dimethoxy-2-methyl-N-[(1R)-1-(naphthalen-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of SOS1 CD (564 to 1049 residues) (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed