Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50019249
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate measured at 20 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50: 180nMAssay Description:Competitive inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617139(CHEMBL5407622)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of cathepsin B in live human U-251MG cells using e Abz-GIVRAK(Dnp)-NH2 as substrate preincubated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617131(CHEMBL5411088)
Affinity DataKi:  42nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617131(CHEMBL5411088)
Affinity DataKi:  46nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617136(CHEMBL5395533)
Affinity DataKi:  49nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617132(CHEMBL5405909)
Affinity DataKi:  49nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617132(CHEMBL5405909)
Affinity DataKi:  55nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataKi:  109nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617136(CHEMBL5395533)
Affinity DataKi:  110nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617137(CHEMBL5401219)
Affinity DataKi:  191nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617135(CHEMBL5409217)
Affinity DataKi:  210nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617131(CHEMBL5411088)
Affinity DataKi:  220nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617133(CHEMBL5432531)
Affinity DataKi:  279nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617134(CHEMBL5413230)
Affinity DataKi:  320nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin S(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataKi:  406nMAssay Description:Inhibition of human cathepsin S using Z-VVR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617135(CHEMBL5409217)
Affinity DataKi:  470nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617137(CHEMBL5401219)
Affinity DataKi:  520nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617134(CHEMBL5413230)
Affinity DataKi:  540nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataKi:  661nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProcathepsin L(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617133(CHEMBL5432531)
Affinity DataKi:  690nMAssay Description:Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617136(CHEMBL5395533)
Affinity DataKi:  860nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617132(CHEMBL5405909)
Affinity DataKi:  1.19E+3nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617137(CHEMBL5401219)
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617132(CHEMBL5405909)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617135(CHEMBL5409217)
Affinity DataKi:  2.34E+3nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617136(CHEMBL5395533)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617133(CHEMBL5432531)
Affinity DataKi:  4.10E+3nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617134(CHEMBL5413230)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activated enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617138(CHEMBL5439563)
Affinity DataKi:  8.21E+3nMAssay Description:Reversible inhibition of human cathepsin B using Z-RR-AMC as substrate assessed as inhibition constant preincubated for 20 mins followed by pre-activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617131(CHEMBL5411088)
Affinity DataKi:  8.81E+3nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617137(CHEMBL5401219)
Affinity DataKi:  1.91E+4nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617134(CHEMBL5413230)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataKi:  2.59E+4nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617135(CHEMBL5409217)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50617133(CHEMBL5432531)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of human cathepsin K using Z-LR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed