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Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50020769
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50633490(CHEMBL5430212)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627875(CHEMBL5401805)
Affinity DataKd:  349nMAssay Description:Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to Avi-tagged WHSC1 (941 to 1240 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567877(US11420970, Example 78)
Affinity DataIC50: 12nMAssay Description:Inhibition of NSD2 in human CGTH-W-1 cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567996(US11420970, Example 198)
Affinity DataIC50: 18nMAssay Description:Inhibition of NSD2 in human CGTH-W-1 cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567900(US11420970, Example 101)
Affinity DataIC50: 34nMAssay Description:Inhibition of NSD2 in human KMS-11-Par cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567900(US11420970, Example 101)
Affinity DataIC50: 40nMAssay Description:Inhibition of NSD2 in human CGTH-W-1 cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567996(US11420970, Example 198)
Affinity DataIC50: 41nMAssay Description:Inhibition of NSD2 in human KMS-11-Par cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM567877(US11420970, Example 78)
Affinity DataIC50: 78nMAssay Description:Inhibition of NSD2 in human KMS-11-Par cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50633488(CHEMBL5441106)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 15N-labeled NSD2 (953 to 1240 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 using H3K36 as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50572785(CHEMBL4874776)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMSET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50075101(CHEMBL3414624)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of 15N-labeled NSD2 (953 to 1240 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 using H3K36 as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627882(CHEMBL5427103)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627880(CHEMBL5418173)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627884(CHEMBL5420895)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627881(CHEMBL5393738)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627883(CHEMBL5402134)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50633489(CHEMBL5431172)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of WHSC1 (941 to 1240 residues) (unknown origin) using biotinylated-RLARRGGVKRISGLI as substrate incubated for 120 mins in presence of [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of 15N-labeled NSD2 (953 to 1240 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 using H3K36 as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629737(CHEMBL5416266)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of NSD3 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629737(CHEMBL5416266)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of NSD2 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of NSD2 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629737(CHEMBL5416266)
Affinity DataIC50: 4.18E+5nMAssay Description:Inhibition of NSD1 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50572786(CHEMBL4876215)
Affinity DataIC50: 8.90E+5nMAssay Description:Inhibition of recombinant NSD2-SET (unknown origin) expressed in Escherichia coli BL21 using H3K36 as substrate preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed