Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50019240
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617044(CHEMBL5429895)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617047(CHEMBL5414435)
Affinity DataIC50: 8.40nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617041(CHEMBL5403087)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617042(CHEMBL5432198)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 360nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as decrease in alpha-MSH induced cAMP level incubated for 1 hr by microplate reader...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617045(CHEMBL5418302)
Affinity DataIC50: 650nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617055(CHEMBL5437236)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617040(CHEMBL5425592)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617052(CHEMBL5411999 | US20250129048, Example 7)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617052(CHEMBL5411999 | US20250129048, Example 7)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE8BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE2A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE4D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE5A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE9A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE10A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE11A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617041(CHEMBL5403087)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human Nav1.5 expressed in CHO cells by whole cell voltage clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617047(CHEMBL5414435)
Affinity DataKi:  0.450nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617052(CHEMBL5411999 | US20250129048, Example 7)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.460nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in CHO cells by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617057(CHEMBL5411590)
Affinity DataKi:  0.490nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from rat MC4R expressed in CHO cells by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617046(CHEMBL5437451 | US20250084084, Example 89)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617043(CHEMBL5416581)
Affinity DataKi:  0.620nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617052(CHEMBL5411999 | US20250129048, Example 7)
Affinity DataKi:  0.770nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617053(CHEMBL5437282 | US20250129048, Example 2)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617051(CHEMBL5411067)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617049(CHEMBL5427992)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617041(CHEMBL5403087)
Affinity DataKi:  5.5nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617054(CHEMBL5398375)
Affinity DataKi:  6.40nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617042(CHEMBL5432198)
Affinity DataKi:  19nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617050(CHEMBL5396032)
Affinity DataKi:  27nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617055(CHEMBL5437236)
Affinity DataKi:  62nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  340nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  840nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617056(CHEMBL5421279)
Affinity DataKi:  910nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi: >1.60E+3nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
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