Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50019664
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataEC50: 21nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 6.70E+3nMAssay Description:Binding affinity to RIPK3 (unknown origin) assessed as dissociation constant by ATP-Competition Binding AssayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 1.30E+3nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constant by ATP-Competition Binding AssayMore data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 230nMAssay Description:Binding affinity to full length MLKL expressed in human HEK293 cells assessed as dissociation constant incubated for 1 hr by ATP-Competition Binding ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetMixed lineage kinase domain-like protein(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 217nMAssay Description:Binding affinity to full length MLKL expressed in human HEK293 cells assessed as dissociation constant incubated for 1 hr by ATP-Competition Binding ...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 1.90E+3nMAssay Description:Binding affinity to RIPK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 680nMAssay Description:Binding affinity to RIPK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 19nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 64nMAssay Description:Binding affinity to RIPK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to full length human MLKL assessed as dissociation constantMore data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 530nMAssay Description:Binding affinity to full length human MLKL assessed as dissociation constantMore data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Mus musculus)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 9.30E+3nMAssay Description:Binding affinity to recombinant mouse MLKL pseudokinase domain (179 to 464 residues) expressed in Sf21 insect cells assessed as dissociation constant...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataEC50: 74nMAssay Description:Inhibition of RIPK3 (unknown origin) expressed in NIH3T3 cells assessed as inhibition of dimerizer-induced pMLKL level by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 105nMAssay Description:Binding affinity to RIPK1 (unknown origin) by ADP-GlO assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 480nMAssay Description:Binding affinity to human wild type partial length RIPK1 (M1/Q307) expressed in bacterial expression system assessed as dissociation constant by bioc...More data for this Ligand-Target Pair
TargetMixed lineage kinase domain-like protein(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 530nMAssay Description:Binding affinity to full length MLKL (unknown origin) expressed in human HEK293 cells assessed as dissociation constant incubated for 30 mins by Comp...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 326nMAssay Description:Binding affinity to human wild type partial length RIPK3 (M1/Q307) expressed in bacterial expression system assessed as dissociation constant by bioc...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataKd: 1.40nMAssay Description:Binding affinity to human RIPK3 assessed as dissociation constantMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human RIPK1 (1-375) residues by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human RIPK1 (1-375) residues by 33P-radiolabeled assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of GST-tagged RipK1 (1-375) residues (unknown origin) by FP-based binding assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human RIPK3 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 2 hrs by ADP-...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
The Walter and Eliza Hall Institute of Medical Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hERG at 10 uMMore data for this Ligand-Target Pair
