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Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50018919
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50602410(CHEMBL5173274)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of SARS-CoV-2 HKU-001a 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM420297(med.21724, Compound 62 | peptidomimetic aldehydes ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50613814(CHEMBL5278228)
Affinity DataIC50: 72nMAssay Description:Inhibition of SARS-CoV-2 3CL protease expressed in escherichia coli measured after 24 hrs by SDS-PAGEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376)
Affinity DataIC50: 190nMAssay Description:Inhibition of SARS-CoV-2 3CL protease measured after 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataIC50: 320nMAssay Description:Inhibition of SARS-CoV-2 3CL protease using HiLyte Fluor488TM-ESATLQSGLRKAK-QXL520TM-NH2 as substrate measured after 5 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50405454(CHEMBL4850298 | US12180156, Parental aldehyde)
Affinity DataIC50: 400nMAssay Description:Inhibition of SARS-CoV-2 3CL protease measured after 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 670nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM509991(Jun9-62-2R)
Affinity DataIC50: 670nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50589772(CHEMBL5082224)
Affinity DataIC50: 680nMAssay Description:Inhibition of SARS-CoV-2 3CL protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM50405463(CHEMBL5267069)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM509991(Jun9-62-2R)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Trypsin using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCaspase-3(Human)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM509991(Jun9-62-2R)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human caspase 3 using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM509991(Jun9-62-2R)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human calpain using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Huaqiao University

Curated by ChEMBL
LigandPNGBDBM496902(PF-07321332 | science.abl4784, 6 | WO2021250648, E...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of SARS-CoV-2 3CL protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed