Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 50018774
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50334671(kaempferol-3-O-alpha-L-(2'', 4''-di-E-p-coumaroyl)...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NorA efflux pump in Staphylococcus aureus 1199B overexpressing NorA gene assessed as reduction in EtBr efflux inhibition by spectrofluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of NorA efflux pump in Staphylococcus aureus 1199B overexpressing NorA gene assessed as reduction in EtBr efflux inhibition by spectrofluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50612389(CHEMBL5266795)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of P-gp mediated efflux in human LS180 cells using digoxin as substrate incubated for 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50027673(Olympicin A)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of MurE ligase activity in Mycobacterium tuberculosis assessed as release of inorganic phosphate by hydrolysis of ATP using UDP-MurNAc-l-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed