Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50019229
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of RIPK2 (unknown origin) incubated for 30 mins in presence of [gamma33P]ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616944(CHEMBL5398151)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of BMPR1B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616956(CHEMBL5422418)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of BMPR1A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of TGFBR2 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of TGFBR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-2B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of ACVR2B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-2A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of ACVR2A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.31E+5nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 2.65E+5nMAssay Description:Inhibition of ACVR1B (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 2.67E+5nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616944(CHEMBL5398151)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ACVR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta by LanthaScreen TR-FRET assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616944(CHEMBL5398151)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616956(CHEMBL5422418)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of ACVRL1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1A (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of TGFBR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of TGFBR1 (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BMPR1B (unknown origin) by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616958(CHEMBL5404016)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616937(CHEMBL5404269)
Affinity DataKi:  6.20nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616956(CHEMBL5422418)
Affinity DataKi:  7nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616939(CHEMBL5434353)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616951(CHEMBL5420022)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616954(CHEMBL5437902)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616944(CHEMBL5398151)
Affinity DataKi:  21nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616938(CHEMBL5436042)
Affinity DataKi:  22nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616941(CHEMBL5428614)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616946(CHEMBL5402879)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616947(CHEMBL5421520)
Affinity DataKi:  88nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616948(CHEMBL5409160)
Affinity DataKi:  118nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616960(CHEMBL5417301)
Affinity DataKi: >200nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616959(CHEMBL5438355)
Affinity DataKi: >200nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616953(CHEMBL5397482)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616952(CHEMBL5408480)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616957(CHEMBL5399442)
Affinity DataKi:  236nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616945(CHEMBL5400260)
Affinity DataKi:  250nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616950(CHEMBL5438139)
Affinity DataKi:  310nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616955(CHEMBL5411422)
Affinity DataKi:  430nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616949(CHEMBL5434246)
Affinity DataKi:  930nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50616940(CHEMBL5420892)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of recombinant C-terminal 6His-tagged human BMPR2 (188 to 517 residues) expressed in Escherichia coli Rosetta assessed as apparent inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
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