Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50020608
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631855(CHEMBL4530216)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ASH1L SET domain (2069 to 2288 residues) (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631853(CHEMBL5429146)
Affinity DataIC50: 0nMAssay Description:Inhibition of rearranged during transfection kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631857(CHEMBL5419782)
Affinity DataIC50: 6nMAssay Description:Inhibition of full length human MTH1 expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYEATS domain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631859(CHEMBL5409682)
Affinity DataIC50: 96nMAssay Description:Inhibition of human N-terminal GST tagged GAS41 (1 to 148 residues) incubated for 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631854(CHEMBL5410484)
Affinity DataIC50: 790nMAssay Description:Inhibition of N-terminal Mocr-tagged ASH1L (2069 to 2288 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631856(CHEMBL4938738)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full length human MTH1 expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208876(4-aminopyrazolo[3,4-d]pyrimidine | 1H-Pyrazolo[3,4...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of rearranged during transfection kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631858(CHEMBL1573062)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibition of human N-terminal GST tagged GAS41 (1 to 148 residues) incubated for 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631860(CHEMBL5407837)
Affinity DataKi:  10nMAssay Description:Binding affinity to human A1AR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50548167(CHEMBL2206133)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity to human A1AR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed