Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50019180
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616247(CHEMBL5410175)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616249(CHEMBL5414515)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells expression system incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616250(CHEMBL5398173)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP12 (500 to 701 end residues) expressed in baculovirus infected Sf9 cells expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616248(CHEMBL5436756)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP1 (2 to 1014 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616245(CHEMBL5407189)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616244(CHEMBL5429007)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616246(CHEMBL5425015)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616251(CHEMBL5417413)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616252(CHEMBL5432380)
Affinity DataIC50: 116nMAssay Description:Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 174nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP5a (1001 to 1327 end residues) expressed in baculovirus infected Sf9 cells expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 227nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP5b (667 to 1166 end residues) expressed in baculovirus infected Sf9 cells expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 325nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged / C-terminal Strep-tagged PARP10 (805 to 1025 end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 453nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP12 (500 to 701 end residues) expressed in baculovirus infected Sf9 cells expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 546nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells expression system incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616253(CHEMBL5438098)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP1 (2 to 1014 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of human recombinant N-terminal 6his-tagged / GST-tagged PARP14 (1470 to 1801 end residues) expressed in baculovirus infected Sf9 cells ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged / C-terminal His-tagged PARP11 (8 to 338 end residues) expressed in baculovirus infected Sf9 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 3.45E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP5b (667 to 1166 end residues) expressed in baculovirus infected Sf9 cells expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP5a (1001 to 1327 end residues) expressed in baculovirus infected Sf9 cells expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616254(CHEMBL5429739)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP1 (2 to 1014 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged / C-terminal Strep-tagged PARP10 (805 to 1025 end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP1 (2 to 1014 end residues) incubated for 1 hr by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant N-terminal 6his-tagged / GST-tagged PARP14 (1470 to 1801 end residues) expressed in baculovirus infected Sf9 cells ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616243(CHEMBL5395820)
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged / C-terminal His-tagged PARP11 (8 to 338 end residues) expressed in baculovirus infected Sf9 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed