Compile Data Set for Download or QSAR
Report error Found 83 Enz. Inhib. hit(s) with all data for entry = 50018161
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50: 0.0660nMAssay Description:Inhibition of AKT1 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of AKT1 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405634(VEVORISERTIB | Vevorisertib)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405634(VEVORISERTIB | Vevorisertib)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405628(CHEMBL5272165)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PI3Kdelta in presence of [p32-gamma]-ATP measured after 2 hrs by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405634(VEVORISERTIB | Vevorisertib)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50503943(CHEMBL4536105)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human HDAC1 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AKT2 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of AKT3 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human PI3Kdelta incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Mouse)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse PI3Kdelta expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405632(CHEMBL5278968)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human HDAC1 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PI3Kalpha incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse PI3Kalpha expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse PI3Kgamma expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human PI3Kgamma incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT2 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PI3Kbeta incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Mouse)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of mouse PI3Kbeta expressed in insect cells assessed as fluorescence polarization incubated for 30 mins by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT3 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405632(CHEMBL5278968)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human HDAC10 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405637(CHEMBL5273641)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-His-tagged recombinant PI3Kalpha (unknown origin) using Alexa Fluor-Kinase Tracer 315 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405631(CHEMBL5286570)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of AKT1 (unknown origin) using Ser/Thr06 peptide substrate measured after 1 hr by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 4nMAssay Description:Inhibition of full-length His-tagged PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405631(CHEMBL5286570)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of AKT3 (unknown origin) using Ser/Thr06 peptide substrate measured after 1 hr by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405632(CHEMBL5278968)
Affinity DataIC50: 5nMAssay Description:Inhibition of human HDAC2 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length His-tagged PI3Kgamma (unknown origin) using L-alpha-phosphatidylinositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405640(CHEMBL5268290)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of N-His-tagged recombinant PI3Kalpha (unknown origin) using Alexa Fluor-Kinase Tracer 315 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM312517(US9604989, Example 5 | 2-[4-(1-Aminocyclobutyl)phe...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human full length his-tagged AKT1 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405632(CHEMBL5278968)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human HDAC11 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 6nMAssay Description:Inhibition of full-length His-tagged mTOR (unknown origin) using L-alpha-phosphatidylinositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50503943(CHEMBL4536105)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human HDAC6 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of PI3Kalpha H1047R mutant in human SK-OV-3 cells assessed as protein phosphorylation incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 7nMAssay Description:Inhibition of full-length His-tagged PI3Kdelta (unknown origin) (unknown origin) using L-alpha-phosphatidylinositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405641(CHEMBL5286800)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PIK3delta (unknown origin) assessed as fluorescence intensity using PIP2 as substrate by jump dilution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50503943(CHEMBL4536105)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human PI3Kdelta by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 16nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50: 16nMAssay Description:Inhibition of human mTOR incubated for 30 mins by ATP competition based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50405630(CHEMBL5280789)
Affinity DataIC50: 18nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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