Compile Data Set for Download or QSAR
Report error Found 102 Enz. Inhib. hit(s) with all data for entry = 50019807
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50192880(CHEMBL3984425 | US9775844, Compound 4 | US10329299...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTarget of rapamycin complex subunit LST8(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623161(Gsk-1059615 | GSK-615 | GSK1059615 | GSK615 | GSK-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623161(Gsk-1059615 | GSK-615 | GSK1059615 | GSK615 | GSK-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of P13Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length human mTOR by immunoprecipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues) incubated for 60 mins in presence of ATP by LANCE Ultra phosphatas...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50177662(CHEMBL3813842)
Affinity DataIC50: 2nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623161(Gsk-1059615 | GSK-615 | GSK1059615 | GSK615 | GSK-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of P13Kalpha (unknown origin) in the presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human P13Kalpha incubated for 2 hrs by fluorescent polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50177662(CHEMBL3813842)
Affinity DataIC50: 3nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of P13Kbeta (unknown origin) in the presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of P13Kdelta (unknown origin) in the presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of N-terminal His-tagged recombinant human P13Kalpha incubated for 60 mins in presence of ATP by kinase-glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623164(CHEMBL5426067)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of full length His-tagged recombinant human P13Kgamma expressed in baculovirus incubated for 60 mins in presence of ATP by kinase-glo lumi...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of P13Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PKB phosphorylation in human BT-20 cells incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PKB phosphorylation in human SK-OV-3 cells incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50607921(CHEMBL5278357)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PKB phosphorylation in human U87 cells incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 4nMAssay Description:Inhibition of C-terminal His-tagged full length P13Kalpha (unknown origin) using l-alpha-phosphatidylinositol as substrate incubated for 120 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50623161(Gsk-1059615 | GSK-615 | GSK1059615 | GSK615 | GSK-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged full length P13Kgamma (unknown origin) using l-alpha-phosphatidylinositol as substrate incubated for 120 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PKBbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50607920(Samotolisib | Ly-3023414 | LY 3023414 | LY-3023414...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant human P13Kalpha in the presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 7nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 7nMAssay Description:Inhibition of C-terminal His-tagged full length P13Kdelta (unknown origin) using l-alpha-phosphatidylinositol as substrate incubated for 120 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50274638(CHEMBL4126156 | US10858355, Example 4)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50324735(CHEMBL568150 | AS605240 | (5E)-5-(QUINOXALIN-6-YLM...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant PI3Kgamma using phosphatidylinositol as substrate in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 8nMAssay Description:Inhibition of PKBalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 9nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50177662(CHEMBL3813842)
Affinity DataIC50: 10nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50341243((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 12nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50623161(Gsk-1059615 | GSK-615 | GSK1059615 | GSK615 | GSK-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PKBbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50405629(CHEMBL5278435)
Affinity DataIC50: 13nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50338197(5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 14nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50266518(CHEMBL4071083)
Affinity DataIC50: 15nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of P13Kgamma (unknown origin) in the presence of ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
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