Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50017481
LigandPNGBDBM50602176(CHEMBL5170320)
Affinity DataKd:  6.20nMAssay Description:Inhibition of human PI3K-delta by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50042559(5-Butyl-2-(2-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50: 0.350nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant wild-type BTK (unknown origin) assessed as inhibition of substrate phosphorylation using peptide substrate in presence of A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50042580(2-Butyl-5-(2-chloro-phenyl)-3-[2'-(1H-tetrazol-5-y...)
Affinity DataIC50: 0.550nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602174(CHEMBL5189739)
Affinity DataIC50: 1nMAssay Description:Inhibition of plasma kallikrein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM426495(US10543199, Compound 45 | US10543199, Compound 76 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human DPP4 expressed in Silkworm baculovirus system preincubated for 30 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602175(UDENAFIL | Udenafil | Zydena | DA-8159)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 14nMAssay Description:Inhibition of CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50602177(CHEMBL5206636)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length human AR stably expressed in human HEK293 cells assessed as luciferase activity incubated for 24 hrs by microplate luminome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataIC50: 40nMAssay Description:Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM322155(US11311541, Example SLx-2119 | US10696660, SLx-211...)
Affinity DataIC50: 105nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed