Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50020725
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataEC50:  5.39E+4nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  2.32E+6nMAssay Description:Inhibition of IDO1 in mouse CT26 cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataEC50:  2.82E+6nMAssay Description:Inhibition of IDO1 in mouse CT26 cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  3.41E+4nMAssay Description:Inhibition of IDO1 in human HCT-116 cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataEC50:  5.08E+4nMAssay Description:Inhibition of IDO1 in human HCT-116 cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetThioredoxin reductase 1, cytoplasmic(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  1.31E+4nMAssay Description:Inhibition of TrxR1 in human HeLa cells incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  3.14E+3nMAssay Description:Inhibition of TrxR1 in human HCT-116 cells incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Mus musculus)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  2.57E+4nMAssay Description:Inhibition of TrxR1 in mouse CT26 cells incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataEC50:  4.56E+4nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-Tryptophan as substrate incubated for 24 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633107(CHEMBL5417869)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633109(CHEMBL5417326)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataIC50: 410nMAssay Description:Inhibition of TDO (unknown origin) using L-Trp as substrate incubated for 75 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 630nMAssay Description:Inhibition of IDO2 (unknown origin) using D-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633108(CHEMBL5430918)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633109(CHEMBL5417326)
Affinity DataIC50: 3.69E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633107(CHEMBL5417869)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633104(CHEMBL5421988)
Affinity DataIC50: 4.37E+3nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633101(CHEMBL5403820)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633105(CHEMBL5422448)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633102(CHEMBL5401999)
Affinity DataIC50: 7.63E+3nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633105(CHEMBL5422448)
Affinity DataIC50: 7.88E+3nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633106(CHEMBL5413180)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633108(CHEMBL5430918)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633101(CHEMBL5403820)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633103(CHEMBL5413849)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633104(CHEMBL5421988)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633102(CHEMBL5401999)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of recombinant human IDO1 using L-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633106(CHEMBL5413180)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 2.22E+4nMAssay Description:Inhibition of IDO2 (unknown origin) using D-Trp as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633103(CHEMBL5413849)
Affinity DataIC50: 2.52E+4nMAssay Description:Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 5.42E+4nMAssay Description:Inhibition of TDO (unknown origin) using L-Trp as substrate incubated for 75 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 2, mitochondrial(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of TrxR2 (unknown origin) incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetThioredoxin reductase 3(Human)
Wannan Medical College

Curated by ChEMBL
LigandPNGBDBM50633100(CHEMBL5412818)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of TrxR3 (unknown origin) incubated for 1 hr in presence of NADPH by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed