Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50017445
TargetSerine/threonine-protein kinase ULK1(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50271371(CHEMBL4125718)
Affinity DataKd:  290nMAssay Description:Binding affinity to wild type ULK1 (unknown origin) expressed in HEK293T cells assessed as dissociation constant measured after 8 mins by SPR analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50528216(CHEMBL4440358)
Affinity DataEC50:  5.70E+3nMAssay Description:Activation of wild type human N-terminal full length SIRT6 deacetylation (8 to 533 residues) expressed in Escherichia coli BL21 (DE3) expression syst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of human SIRT6 using acetylated histone H3K9 as peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed