Compile Data Set for Download or QSAR
Report error Found 135 Enz. Inhib. hit(s) with all data for entry = 50016002
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043501(CHEMBL3355509)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043501(CHEMBL3355509)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 21nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 21nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 32nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591084(CHEMBL5186508)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 40nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 44nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591084(CHEMBL5186508)
Affinity DataIC50: 50nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50390791(CHEMBL2070615)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 56nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 71nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 74nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 81nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50044004(CHEMBL3356433)
Affinity DataIC50: 89nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50: 91nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50591314(CHEMBL5202859)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
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