Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50015837
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590056(CHEMBL5171547)
Affinity DataIC50: 10nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590063(CHEMBL5184087)
Affinity DataIC50: 11nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590051(CHEMBL5184590)
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590054(CHEMBL5201901)
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 16nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 19nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590064(CHEMBL5195849)
Affinity DataIC50: 29nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590059(CHEMBL5201816)
Affinity DataIC50: 30nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 34nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590065(CHEMBL5185398)
Affinity DataIC50: 34nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590057(CHEMBL5183723)
Affinity DataIC50: 40nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590053(CHEMBL5170314)
Affinity DataIC50: 49nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590058(CHEMBL5185573)
Affinity DataIC50: 51nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590066(CHEMBL5193498)
Affinity DataIC50: 53nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590062(CHEMBL5208418)
Affinity DataIC50: 70nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590060(CHEMBL5183879)
Affinity DataIC50: 75nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590055(CHEMBL5191638)
Affinity DataIC50: 78nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590052(CHEMBL5181797)
Affinity DataIC50: 88nMAssay Description:Inhibition of SOS1 in human DLD-1 cells assessed as reduction in ERK phosphorylation incubated for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.90E+3nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 2.10E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 4.30E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 6.50E+3nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 8.70E+3nMAssay Description:Time-dependent inhibition of CYP2D6 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.24E+4nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.30E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 1.46E+4nMAssay Description:Time-dependent inhibition of CYP2C9 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition by LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 1.58E+4nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 3.87E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 3.91E+4nMAssay Description:Time-dependent inhibition of CYP2C8 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 4.33E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 4.52E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 5.43E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590050(CHEMBL5203150)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590049(CHEMBL5209105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition by LC/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 1.00E+5nMAssay Description:Time-dependent inhibition of CYP3A4 (unknown origin) at 2 ul pre-incubated for 30 mins in presence or absence of NADPH incubated for 10 mins by LC/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50590061(CHEMBL5196432)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition by LC/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed