Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50019491
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619723(CHEMBL4080764)
Affinity DataIC50: 130nMAssay Description:Inhibition of HIV-1 RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 210nMAssay Description:Inhibition of HIV-1 RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia coli using 5-GTTTTCTTTTCCCCCCTGAC-3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619722(CHEMBL1997963)
Affinity DataIC50: 600nMAssay Description:Inhibition of HIV-1 RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50162042(CHEMBL1928097)
Affinity DataIC50: 650nMAssay Description:Inhibition of HIV-1 reverse transcriptase associated RNase H activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50592653(CHEMBL5173438)
Affinity DataIC50: 720nMAssay Description:Inhibition of HIV-1 reverse transcriptase RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase activity incubated for 30 mins by multilabel counter pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619725(CHEMBL5407516)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal 6-his-tagged HIV-1 reverse transcriptase RNase H (427 to 560 residues) transformed in Escherichia coli B21 (DE3) at pH 8.0 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619727(CHEMBL5418820)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase RNase-associated RNase H expressed in Escherichia coli M15 using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619726(CHEMBL5434992)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase associated RNase H using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluorescein/5CAAAAGAAAAGGGGGGACUG-3-Dabcyl as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50162042(CHEMBL1928097)
Affinity DataIC50: 2.60E+3nMAssay Description:Non-competitive inhibition of HIV reverse transcriptase polymerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619725(CHEMBL5407516)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of N-terminal 6-his-tagged HIV-1 reverse transcriptase RNase H (427 to 560 residues) transformed in Escherichia coli B21 (DE3) at pH 7.4 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50579010(CHEMBL4865520)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619728(CHEMBL5396810)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase associated DNA polymerase independent RNase H activity using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619724(CHEMBL5401719)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase associated DNA polymerase independent RNase H activity using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619724(CHEMBL5401719)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIV-1 RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50142734((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of HIV-1 RNase H polymerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619729(CHEMBL5439749)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase RNase H activity expressed in Escherichia coli M15 using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluorescein/5CAAAAGAAAAGG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50619726(CHEMBL5434992)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant HIV-1 His-tagged LEDGF-dependent integrase preincubated for 1 hr followed by compound addition and measured after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant HIV-1 His-tagged LEDGF integrase preincubated for 30 mins followed by FLAG-LEDGF addition and measured after 4 hrs by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant HIV-1 LEDGF-independent full length His-tagged integrase expressed in Escherichia coli BL21 (DE3) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of recombinant HIV-1 LEDGF-dependent full length His-tagged integrase expressed in Escherichia coli BL21 (DE3) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50142734((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of HIV-1 integrase 3' processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50142734((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed