Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50019923
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PKAC-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PKAC-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624682(CHEMBL5414047)
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624686(CHEMBL5415336)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50173319(CHEMBL3809020 | US10023564, Example 11)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 42nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 160nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 220nMAssay Description:Time dependent inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624684(CHEMBL5406336)
Affinity DataIC50: 236nMAssay Description:Inhibition of GRK2 (unknown origin) using CRRREEEEESAAA as substrate measured for 120 mins in presence of ATP by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624683(CHEMBL5412633)
Affinity DataIC50: 250nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624683(CHEMBL5412633)
Affinity DataIC50: 260nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM283996(US10023564, Example 22 | E22)
Affinity DataIC50: 380nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50173320(GSK-180736A | GSK180736A | US10023564, Compound GS...)
Affinity DataIC50: 390nMAssay Description:Inhibition of GRK2 (unknown origin) using CRRREEEEESAAA as substrate measured for 120 mins in presence of ATP by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50173320(GSK-180736A | GSK180736A | US10023564, Compound GS...)
Affinity DataIC50: 770nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624685(CHEMBL5398985)
Affinity DataIC50: 1.10E+3nMAssay Description:Time dependent inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human GRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624685(CHEMBL5398985)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50265871(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of GRK2 (unknown origin) measured for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50246208(cid_274122 | CHEMBL487046 | 2-(3,4,5-trihydroxy-6-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of C-terminal his6-tagged human GRK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27826(4-fluoro-2-[(2-{[2-methoxy-4-(1-propylpiperidin-4-...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Mus musculus)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM357857(US10214536, Amlexanox | Aphthasol)
Affinity DataIC50: 8.86E+3nMAssay Description:Inhibition of mouse GRK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50265871(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of C-terminal his6-tagged human GRK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27826(4-fluoro-2-[(2-{[2-methoxy-4-(1-propylpiperidin-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50624685(CHEMBL5398985)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal his6-tagged human GRK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal his6-tagged human GRK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50529465(CHEMBL4464632)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed