Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50016538
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataKd:  2.00E+4nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataKd:  3.98E+3nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataKd:  631nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataKd:  501nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataKd:  6.31E+4nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595667(CHEMBL5181350)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50: 5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50: 5nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595666(CHEMBL5200126)
Affinity DataIC50: 13nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50: 15nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595660(CHEMBL5185576)
Affinity DataIC50: 15nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50: 16nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50: 16nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595665(CHEMBL5186129)
Affinity DataIC50: 27nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50: 31nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 32nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 32nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595662(CHEMBL5197383)
Affinity DataIC50: 35nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595664(CHEMBL5207346)
Affinity DataIC50: 39nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595659(CHEMBL5181827)
Affinity DataIC50: 39nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595663(CHEMBL5175091)
Affinity DataIC50: 140nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataIC50: 187nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 279nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595667(CHEMBL5181350)
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataIC50: 800nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595666(CHEMBL5200126)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595662(CHEMBL5197383)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595663(CHEMBL5175091)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595660(CHEMBL5185576)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595665(CHEMBL5186129)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595667(CHEMBL5181350)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595662(CHEMBL5197383)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595659(CHEMBL5181827)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595664(CHEMBL5207346)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595666(CHEMBL5200126)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312172(Alternative Preparation | US9616063, 3 | US1001643...)
Affinity DataIC50: 6.00E+3nMAssay Description:Competitive inhibition of human recombinant CYP3A4 using coumarin as substrate preincubated with enzyme for 10 mins followed by NADPH addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50595665(CHEMBL5186129)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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