Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50019486
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619628(CHEMBL5404362)
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619628(CHEMBL5404362)
Affinity DataIC50: 0.125nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.264nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Escherichia coli beta-lactamase CTX-M-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Escherichia coli beta-lactamase TEM-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli beta-lactamase CTX-M-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619647(CHEMBL5409555)
Affinity DataIC50: 14nMAssay Description:Inhibition of Pseudomonas aeruginosa AmpCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619632(CHEMBL5396318)
Affinity DataIC50: 20nMAssay Description:Inhibition of VIM1 (unknown origin) using dicefalotinodifluorofluorescein as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 26nMAssay Description:Inhibition of Escherichia coli beta-lactamase TEM-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella oxytoca)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619646(CHEMBL5483057)
Affinity DataIC50: 44nMAssay Description:Inhibition of Klebsiella pneumoniae beta-lactamase KPC-2 using nitrocefin as substrate measured after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619630(CHEMBL5417591)
Affinity DataIC50: 130nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase OXA-1(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Escherichia coli beta-lactamase OXA-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619638(CHEMBL5432245)
Affinity DataIC50: 150nMAssay Description:Inhibition of NDM1 (unknown origin) using nitrocefin as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella oxytoca)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 186nMAssay Description:Inhibition of Klebsiella pneumoniae beta-lactamase KPC-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619632(CHEMBL5396318)
Affinity DataIC50: 300nMAssay Description:Inhibition of NDM1 (unknown origin) using dicefalotinodifluorofluorescein as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619634(CHEMBL5437270)
Affinity DataIC50: 322nMAssay Description:Inhibition of NDM1 (unknown origin) by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619633(CHEMBL5284352)
Affinity DataIC50: 374nMAssay Description:Inhibition of NDM1 (unknown origin) by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619626(CHEMBL4177035)
Affinity DataIC50: 526nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50542679(CHEMBL4639584)
Affinity DataIC50: 650nMAssay Description:Inhibition of NDM1 (unknown origin) using fluorocillin as substrate by measuring difluoro-fluorescein formed using fluorescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50585852(CHEMBL4790849)
Affinity DataIC50: 700nMAssay Description:Inhibition of NDM1 (unknown origin) by differential scanning fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 845nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50542679(CHEMBL4639584)
Affinity DataIC50: 860nMAssay Description:Inhibition of VIM1 (unknown origin) using fluorocillin as substrate by measuring difluoro-fluorescein formed using fluorescence plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella oxytoca)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 869nMAssay Description:Inhibition of Klebsiella pneumoniae beta-lactamase KPC-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619643(CHEMBL5396533)
Affinity DataIC50: 910nMAssay Description:Inhibition of NDM1 (unknown origin) using fluorescent cephalosporin FC5 as substrate incubated for 15 mins followed by substrate addition measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 923nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619642(NITRILOTRIACETIC ACID | CHEBI:44557)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of NDM1 (unknown origin) using fluorescent cephalosporin FC5 as substrate incubated for 15 mins followed by substrate addition measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50339145(trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of Acinetobacter baumannii beta-lactamase OXA-23More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619644(CHEMBL5412587)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of NDM1 (unknown origin) using cefazolin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase OXA-1(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of Escherichia coli beta-lactamase OXA-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619629(CHEMBL4087144)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619631(CHEMBL4217706)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50140754(CHEMBL434965 | (R)-1-((S)-3-Mercapto-2-methyl-prop...)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619626(CHEMBL4177035)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase L1 type 3(Pseudomonas maltophilia)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50089390(CHEMBL3577963)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 preincubated for 30 mins followed by nitrocefin solution measured by UV based microtitre plate analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619627(CHEMBL4169182)
Affinity DataIC50: 3.37E+4nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619645(NACUBACTAM | Nacubactam | FPI-1459 | RG-6080 | RG6...)
Affinity DataIC50: 4.64E+4nMAssay Description:Inhibition of Acinetobacter baumannii beta-lactamase OXA-23More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619627(CHEMBL4169182)
Affinity DataIC50: 6.48E+4nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50: 1.57E+5nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619648(CHEMBL2031559)
Affinity DataKi:  85nMAssay Description:Binding affinity to Escherichia coli CTX-M-14 assessed as inhibition constant using nitrocefin as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Escherichia coli)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619648(CHEMBL2031559)
Affinity DataKi:  280nMAssay Description:Binding affinity to Escherichia coli CTX-M-27 assessed as inhibition constant using nitrocefin as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619635(CHEMBL4536585)
Affinity DataKi:  290nMAssay Description:Binding affinity to NDM1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using MEM as substrate by Dixon pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619637(CHEMBL5412338)
Affinity DataKi:  840nMAssay Description:Binding affinity to NDM1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using IPM as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619639(CHEMBL5406124)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity to VIM1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619641(CHEMBL5436805)
Affinity DataKi:  4.69E+3nMAssay Description:Binding affinity to VIM1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619640(CHEMBL5409261)
Affinity DataKi:  5.50E+3nMAssay Description:Binding affinity to VIM1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM153698(L-CS319)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to NDM1 (unknown origin) assessed as inhibition constant by measuring imipenem hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619636(CHEMBL5402781)
Affinity DataKi:  9.82E+3nMAssay Description:Binding affinity to NDM1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using IPM as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50619635(CHEMBL4536585)
Affinity DataKi:  1.46E+4nMAssay Description:Binding affinity to VIM1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using MEM as substrate by Dixon pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM153699(D-CS319)
Affinity DataKi:  1.90E+4nMAssay Description:Binding affinity to NDM1 (unknown origin) assessed as inhibition constant by measuring imipenem hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
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