Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50015770
TargetDual specificity protein kinase CLK1(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to CLK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  0.0960nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to CLK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  0.610nMAssay Description:Binding affinity to CLK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CLK4 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CLK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human CLK2 Long (130 to 496 residues) expressed in Escherichia coli BL21 (DE3) Turner using GSK3 as substrate incubated for 60 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK1(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CLK1 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human CLK4 (146 to 480 residues) expressed in Escherichia coli BL21 (DE3) Turner using MBP as substrate incubated for 60 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK1(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human CLK1 Long (148 to 484 residues) expressed in Escherichia coli BL21 (DE3) Turner incubated for 60 mins in presence of [gamma-32P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589476(CHEMBL5185809)
Affinity DataIC50: 14nMAssay Description:Inhibition of CLK4 (unknown origin) assessed as reduction in SRSF10 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Mouse)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50026622(CHEMBL408982)
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged recombinant mouse CLK4 expressed in Escherichia coli using RSPSYGRSRSRSRSRSRSRSRSNSRSRSY as substrate in presence of [gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CLK3 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589476(CHEMBL5185809)
Affinity DataIC50: 24nMAssay Description:Inhibition of CLK4 (unknown origin) assessed as reduction in SRSF1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human CLK3-4 (275 to 632 residues) expressed in Escherichia coli BL21 (DE3) Turner using S6-peptide as substrate incubated for 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK1(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589476(CHEMBL5185809)
Affinity DataIC50: 44nMAssay Description:Inhibition of CLK1 (unknown origin) assessed as reduction in SRSF10 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50342913((5-(4-((5-methylfuran-2-yl)methylamino)quinazolin-...)
Affinity DataIC50: 136nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589476(CHEMBL5185809)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
University of Canterbury

Curated by ChEMBL
LigandPNGBDBM50589476(CHEMBL5185809)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed