Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50016351
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518135(US11111247, Example 1)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518180(US11111247, Example 11)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518172(US11111247, Example 8)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepcidin(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518170(US11111247, Example 6)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518169(US11111247, Example 5)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594431(CHEMBL5178082)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518156(US11111247, Example 2)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 27nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepcidin(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 28nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepcidin(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 34nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 39nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594432(CHEMBL5181658)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 48nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepcidin(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 58nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 61nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594430(CHEMBL5199942)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594429(CHEMBL5187962)
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 98nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50: 119nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 176nMAssay Description:Inhibition of FGFR3 (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50: 207nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518180(US11111247, Example 11)
Affinity DataIC50: 212nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518156(US11111247, Example 2)
Affinity DataIC50: 245nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 251nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518170(US11111247, Example 6)
Affinity DataIC50: 346nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518172(US11111247, Example 8)
Affinity DataIC50: 350nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50: 383nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518135(US11111247, Example 1)
Affinity DataIC50: 384nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 538nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518169(US11111247, Example 5)
Affinity DataIC50: 661nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594433(CHEMBL5189003)
Affinity DataIC50: 793nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 901nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50594429(CHEMBL5187962)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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