Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50015761
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444954(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444965(6-((1-(2-chloro-5-methoxy-3'-(trifluoromethyl)-[1,...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444937(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217544(US9212182, 508 | US9212182, 509)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217481(US9212182, 469 | US9212182, 470)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444875(US10668067, Example 1-36 | 6-((2-chloro-3',5-dimet...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444876(US10668067, Example 1-37 | 6-((2-chloro-5-methoxy-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444897(US10668067, Example 1-58 | 6-((2-chloro-4'-fluoro-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444870(6-((2-chloro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444866(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444896(US10668067, Example 1-57 | 6-((2-chloro-4'-fluoro-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444881(US10668067, Example 1-42 | 6-((5-chloro-2-methoxy-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444891(US10668067, Example 1-52 | 6-((2-chloro-3',4',5'-t...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444924(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethyl)-4...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444893(US10668067, Example 1-54 | 6-((2,4'-dichloro-3'-cy...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444884(US10668067, Example 1-45 | 6-((2-chloro-5-methoxy-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444882(US10668067, Example 1-43 | 6-((5-chloro-2-methoxy-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444970(Methyl (2-chloro-5-methoxy-3′-(trifluorometh...)
Affinity DataIC50: 167nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589388(CHEMBL5200258)
Affinity DataIC50: 270nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50237935(CHEMBL4071624)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589390(CHEMBL5176623)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589391(CHEMBL5194714)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444870(6-((2-chloro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 5.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589389(CHEMBL5204213)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 9.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444937(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)
Affinity DataIC50: 1.10E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444897(US10668067, Example 1-58 | 6-((2-chloro-4'-fluoro-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444875(US10668067, Example 1-36 | 6-((2-chloro-3',5-dimet...)
Affinity DataIC50: 1.70E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444954(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Time dependent inhibition of CYP2D6 (unknown origin) preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444954(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Time dependent inhibition of CYP2D6 (unknown origin) incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM217455(US9212182, 431)
Affinity DataIC50: 3.20E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444876(US10668067, Example 1-37 | 6-((2-chloro-5-methoxy-...)
Affinity DataIC50: 3.50E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human Nav1.5 at -50 mV holding potential by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444881(US10668067, Example 1-42 | 6-((5-chloro-2-methoxy-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444896(US10668067, Example 1-57 | 6-((2-chloro-4'-fluoro-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444891(US10668067, Example 1-52 | 6-((2-chloro-3',4',5'-t...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444866(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444920(6-((2-fluoro-5-methoxy-3'-(trifluoromethyl)-4- | U...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444924(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethyl)-4...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444954(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
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