Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50015760
TargetAurora kinase B-B(African clawed frog)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 3nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50010462(CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human BRAF V600E mutant using 5-Fl-SGQLIDSMANSFV-NH2 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50010462(CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...)
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type human BRAF using 5-Fl-SGQLIDSMANSFV-NH2 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A-A(African clawed frog)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50: 25nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50010462(CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human CRAF using 5-Fl-SGQLIDSMANSFV-NH2 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed