Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50016146
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50130285(6-Bromo-1-(4-methoxy-3-piperazin-1-yl-benzenesulfo...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328379(US9663498, Example 19 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 7.10nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592785(CHEMBL5206617)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50019754(LU-AE58054 | IDALOPIRDINE)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592784(CHEMBL5177311)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human 5HT6R expressed in CHO cells assessed as inhibition of 5HT-stimulated cAMP accumulation incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 4.02E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592784(CHEMBL5177311)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328379(US9663498, Example 19 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592785(CHEMBL5206617)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50130285(6-Bromo-1-(4-methoxy-3-piperazin-1-yl-benzenesulfo...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328393(US9663498, Example 33 | 3-(difluoromethyl)-6-bromo...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328408(US9663498, Example 58 | 5-fluoro-1-((4-methoxy-3-(...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328383(US9663498, Example 23 | 3-(difluoromethyl)-5-fluor...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328387(US9663498, Example 27 | 5-bromo-3-(difluoromethyl)...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328385(US9663498, Example 25 | 5-chloro-3-(difluoromethyl...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328409(US9663498, Example 60 | 5-chloro-1-((4-methoxy-3-(...)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50019754(LU-AE58054 | IDALOPIRDINE)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592783(CHEMBL5201491)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328410(US9663498, Example 62 | 5-bromo-1-((4-methoxy-3-(p...)
Affinity DataKi:  0.870nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM50592786(CHEMBL5187416)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328377(US9663498, Example 17 | 6-fluoro-1-((4-methoxy-3-(...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed