Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50017295
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  6.27E+3nMAssay Description:Inhibition of SerpinA3n in mouse ScN2a cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataKd:  2.60E+4nMAssay Description:Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  8.64E+3nMAssay Description:Inhibition of SerpinA3n in mouse ScGT1 cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  1.93E+4nMAssay Description:Inhibition of SerpinA3n in mouse ScGT1 cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine protease inhibitor A3N(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataEC50:  1.12E+4nMAssay Description:Inhibition of SerpinA3n in mouse ScN2a cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataIC50: 95nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMajor prion protein(Mouse)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)

Curated by ChEMBL
LigandPNGBDBM50600940(CHEMBL5081846)
Affinity DataIC50: 950nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed