Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50016769
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50228080(Spiranolactone | S-(2'R,7R,8R,9S,10R,13S,14S)-10,1...)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human wild-type mineralocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of aldosterone-induced transcripti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50228080(Spiranolactone | S-(2'R,7R,8R,9S,10R,13S,14S)-10,1...)
Affinity DataIC50: 9.60nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50228080(Spiranolactone | S-(2'R,7R,8R,9S,10R,13S,14S)-10,1...)
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]-methyltrienolene from human androgen receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 178nMAssay Description:Antagonist activity at human wild-type mineralocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of aldosterone-induced transcripti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 226nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 256nMAssay Description:Antagonist activity at human wild-type mineralocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of aldosterone-induced transcripti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 276nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50228080(Spiranolactone | S-(2'R,7R,8R,9S,10R,13S,14S)-10,1...)
Affinity DataIC50: 6.05E+3nMAssay Description:Displacement of [3H]-dexamethasone from recombinant full length human glucocorticoid receptor expressed in baculovirus infected insect cells incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 1.70E+4nMAssay Description:Displacement of [3H]-methyltrienolene from human androgen receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 5.38E+4nMAssay Description:Displacement of [3H]-dexamethasone from recombinant full length human glucocorticoid receptor expressed in baculovirus infected insect cells incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50228080(Spiranolactone | S-(2'R,7R,8R,9S,10R,13S,14S)-10,1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated ove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-methyltrienolene from human androgen receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated ove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-dexamethasone from recombinant full length human glucocorticoid receptor expressed in baculovirus infected insect cells incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-estradiol from recombinant full-length human estrogen beta receptor expressed in baculovirus infected insect cells incubated ove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50004519(CHEMBL2181929)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597078(CHEMBL5181002)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597086(CHEMBL5187656)
Affinity DataKi:  152nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597084(CHEMBL5174401)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597087(CHEMBL5181278)
Affinity DataKi:  163nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597084(CHEMBL5174401)
Affinity DataKi:  201nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597083(CHEMBL5171957)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597083(CHEMBL5171957)
Affinity DataKi:  342nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597078(CHEMBL5181002)
Affinity DataKi:  357nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597087(CHEMBL5181278)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597085(CHEMBL5183454)
Affinity DataKi:  549nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597081(CHEMBL5184647)
Affinity DataKi:  596nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597077(CHEMBL5172350)
Affinity DataKi:  607nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597081(CHEMBL5184647)
Affinity DataKi:  611nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597086(CHEMBL5187656)
Affinity DataKi:  626nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597076(CHEMBL5176336)
Affinity DataKi:  735nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597068(CHEMBL5201004)
Affinity DataKi:  740nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597085(CHEMBL5183454)
Affinity DataKi:  808nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597076(CHEMBL5176336)
Affinity DataKi:  853nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597080(CHEMBL5207249)
Affinity DataKi:  1.24E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597080(CHEMBL5207249)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597073(CHEMBL5182687)
Affinity DataKi:  1.37E+3nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597077(CHEMBL5172350)
Affinity DataKi:  1.56E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597082(CHEMBL5204612)
Affinity DataKi:  1.75E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597070(CHEMBL5186524)
Affinity DataKi:  1.92E+3nMAssay Description:Displacement of [3H]-aldosterone from recombinant human mineralocorticoid receptor expressed in baculovirus infected insect cells incubated overnight...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597068(CHEMBL5201004)
Affinity DataKi:  1.96E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597070(CHEMBL5186524)
Affinity DataKi:  3.77E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597073(CHEMBL5182687)
Affinity DataKi:  4.31E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597079(CHEMBL5207123)
Affinity DataKi:  5.67E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597071(CHEMBL5191961)
Affinity DataKi:  6.88E+3nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597074(CHEMBL5197264)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]-aldosterone from rat mineralocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597074(CHEMBL5197264)
Affinity DataKi:  1.96E+4nMAssay Description:Displacement of [3H]-dexamethasone from rat glucocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597080(CHEMBL5207249)
Affinity DataKi:  2.22E+4nMAssay Description:Displacement of [3H]-dexamethasone from rat glucocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50597079(CHEMBL5207123)
Affinity DataKi:  2.54E+4nMAssay Description:Displacement of [3H]-dexamethasone from rat glucocorticoid receptor incubated overnight by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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