Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50016904
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataKd:  84nMAssay Description:Binding affinity to human recombinant full length NLRP3 transfected in HEK293F cells assessed as dissociation constant incubated for 40 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598221(CHEMBL4288808)
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 120nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598210(CHEMBL5208422)
Affinity DataIC50: 130nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598218(CHEMBL5192289)
Affinity DataIC50: 190nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598205(CHEMBL5180250)
Affinity DataIC50: 190nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598195(CHEMBL5194587)
Affinity DataIC50: 210nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598209(CHEMBL5205215)
Affinity DataIC50: 210nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598208(CHEMBL5184435)
Affinity DataIC50: 280nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598199(CHEMBL5177480)
Affinity DataIC50: 300nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50: 300nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598203(CHEMBL5175251)
Affinity DataIC50: 320nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598200(CHEMBL5199507)
Affinity DataIC50: 340nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598220(CHEMBL5207986)
Affinity DataIC50: 440nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598198(CHEMBL5186893)
Affinity DataIC50: 460nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598204(CHEMBL5204830)
Affinity DataIC50: 470nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598215(CHEMBL5170902)
Affinity DataIC50: 510nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598212(CHEMBL5192499)
Affinity DataIC50: 620nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598202(CHEMBL5188605)
Affinity DataIC50: 660nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598196(CHEMBL5175584)
Affinity DataIC50: 680nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598206(CHEMBL5191131)
Affinity DataIC50: 750nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598213(CHEMBL5206241)
Affinity DataIC50: 760nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598194(CHEMBL5196758)
Affinity DataIC50: 790nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 910nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598219(CHEMBL5199637)
Affinity DataIC50: 930nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598197(CHEMBL5202588)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598207(CHEMBL5195982)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598216(CHEMBL5184697)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598214(CHEMBL5172777)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598201(CHEMBL5209001)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598217(CHEMBL5193897)
Affinity DataIC50: 7.58E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNLR family CARD domain-containing protein 4(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598203(CHEMBL5175251)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNLR family CARD domain-containing protein 4(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598209(CHEMBL5205215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNLR family CARD domain-containing protein 4(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetInterferon-inducible protein AIM2(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598203(CHEMBL5175251)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetInterferon-inducible protein AIM2(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598209(CHEMBL5205215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetInterferon-inducible protein AIM2(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed