Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50016472
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 6nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 14nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 25nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 36nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 48nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human HDAC3 preincubated with enzyme for 2 hrs followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataIC50: 90nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 514nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 2.66E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  2nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as rate constant (k-2) of EI complex using (Ac-Leu-Gly-Lys(Ac)-AMC as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  6nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  7nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as rate constant (k-2) of EI complex using (Ac-Leu-Gly-Lys(Ac)-AMC as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  13nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  24nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataKi:  25nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  27nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as apparent inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  31nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  39nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataKi:  40nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  57nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  73nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as apparent inhibition constant using (Ac-Leu-Gly-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM476626(N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnama...)
Affinity DataKi:  103nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  590nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as equilibrium inhibition constant (Ki,1) using (Ac-Leu-Gly-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  590nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as equilibrium inhibition constant (Ki,1) using (Ac-Leu-Gly-Lys(Ac)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  700nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as equilibrium inhibition constant (Ki,1) using (Ac-Leu-Gly-Lys(Ac)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as equilibrium inhibition constant (Ki,1) using (Ac-Leu-Gly-Lys(Ac)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed