Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50016880
TargetCathepsin S(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin S(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 1nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin S(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130402(US8822505, 2)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155979(US9018214, 30)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155971(US9018214, 22)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155950(US9018214, 1)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155953(US9018214, 4)
Affinity DataIC50: 13nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130402(US8822505, 2)
Affinity DataIC50: 36nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155959(US9018214, 10)
Affinity DataIC50: 51nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM155962(US9018214, 13)
Affinity DataIC50: 59nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 410nMAssay Description:Inhibition of human Cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130413(US8822505, 13)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130402(US8822505, 2)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM240596(US9409882, 1)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598056(CHEMBL403671)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598057(CHEMBL254337)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228935((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228946((E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(5-(2-(tr...)
Affinity DataKi:  6nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228933((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-(N-methyl...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228939((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  12nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228937((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  14nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228929((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-isopropox...)
Affinity DataKi:  180nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCoagulation factor X(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50228942((E)-N-(1-(5-(2-tert-butylphenyl)pyridin-2-yl)-2-ox...)
Affinity DataKi:  2.33E+3nMAssay Description:Binding affinity to Coagulation factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed