Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50017856
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605543(CHEMBL5207711)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605540(CHEMBL5171553)
Affinity DataIC50: 9nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50521249(CHEMBL4452819)
Affinity DataIC50: 19nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 36nMAssay Description:Inhibition of p90RSK phosphorylation in human NCI-H358 cells harboring KRAS G12C mutant measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50521250(CHEMBL4475526)
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50521250(CHEMBL4475526)
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605541(CHEMBL5192093)
Affinity DataIC50: 117nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605541(CHEMBL5192093)
Affinity DataIC50: 117nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605542(CHEMBL5190874)
Affinity DataIC50: 135nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605544(CHEMBL5173371)
Affinity DataIC50: 138nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605538(CHEMBL5185314)
Affinity DataIC50: 171nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605538(CHEMBL5185314)
Affinity DataIC50: 171nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527056(CHEMBL4536127)
Affinity DataIC50: 496nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of p90RSK phosphorylation in human PC-9 cells measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605539(CHEMBL5172544)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605537(CHEMBL5183988)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of p90RSK phosphorylation in human Calu-6 cells harboring KRAS Q61K measured for 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed