Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50015735
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4D7 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4C1 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4B2 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4B1 by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4B2 catalytic domain by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589214(DUTOGLIPTIN | Dutogliptin | Phx1149 | PHX1149 | US...)
Affinity DataIC50: 25nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589215(CHEMBL5190515)
Affinity DataIC50: 30nMAssay Description:Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 using 2-trans-dodecenoyl-CoA as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589218(CHEMBL5200108)
Affinity DataIC50: 87nMAssay Description:Inhibition of CDK2 (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589217(CHEMBL5169558)
Affinity DataIC50: 330nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50589216(CHEMBL5174930)
Affinity DataIC50: 400nMAssay Description:Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 using 2-trans-dodecenoyl-CoA as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNeutrophil elastase(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50516762(CHEMBL4474485)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human Neutrophil elastase using MeO-SucAlaAla-Pro-Val-AMC as substrate measured for 30 mins by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to DPP-4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProlyl endopeptidase FAP(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataKi:  5nMAssay Description:Binding affinity to FAP (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50279653(CHEMBL4177136)
Affinity DataKi:  235nMAssay Description:Binding affinity to human CA-I assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50279653(CHEMBL4177136)
Affinity DataKi:  480nMAssay Description:Binding affinity to human CA-II assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50279676(CHEMBL4159776)
Affinity DataKi:  504nMAssay Description:Binding affinity to human CA-II assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50279676(CHEMBL4159776)
Affinity DataKi:  6.35E+3nMAssay Description:Binding affinity to human CA-I assessed as inhibition constant preincubated for 15 mins by bromothymol blue staining based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed