Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50015291
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585035(CHEMBL5084411)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585030(CHEMBL5091232)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585037(CHEMBL5085562)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585042(CHEMBL5069528)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585031(CHEMBL5077302)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585039(CHEMBL5081773)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585044(CHEMBL5088392)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585043(CHEMBL5094869)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585038(CHEMBL5081315)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585036(CHEMBL5094241)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585034(CHEMBL5093637)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585040(CHEMBL5077710)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585041(CHEMBL5094099)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585033(CHEMBL5085826)
Affinity DataIC50: 134nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50585032(CHEMBL5078821)
Affinity DataIC50: 178nMAssay Description:Antagonist activity at human PAR-1 expressed in HEK293 cells assessed as reduction in TRAP induced calcium signal at 3 uM by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585040(CHEMBL5077710)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585042(CHEMBL5069528)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585044(CHEMBL5088392)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cells at 60 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585037(CHEMBL5085562)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cells at 60 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585037(CHEMBL5085562)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585044(CHEMBL5088392)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585041(CHEMBL5094099)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585036(CHEMBL5094241)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585034(CHEMBL5093637)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585039(CHEMBL5081773)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585043(CHEMBL5094869)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585038(CHEMBL5081315)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585035(CHEMBL5084411)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50585038(CHEMBL5081315)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cells at 60 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed