Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50016052
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50148911(3beta-hydroxyurs-12-en-28-oic acid | (3beta)-3-hyd...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human SENP1 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591767(CHEMBL5206456)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SENP1 (unknown origin) assessed as reduction in deSUMOylation of RanGAP1-SUMO2 using RanGAP1-SUMO2 as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of His-tagged human SENP2 (364 to 589 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of His-tagged human SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of His-tagged human SENP7 expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins by Coomassie staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591764(CHEMBL5207368)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human SENP2 using QTGG-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591766(CHEMBL5188918)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant human SENP2 in presence of DTT by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591765(CHEMBL5204661)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human SENP6 using Ac-LRGG-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591763(CHEMBL5194248)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human SENP2 using QTGG-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human SENP6 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50565347(CHEMBL4789677)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant human SENP2 in presence of DTT by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human SENP2 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591764(CHEMBL5207368)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human SENP1 using QTGG-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591763(CHEMBL5194248)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human SENP1 using QTGG-AFC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591762(CHEMBL470172)
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591768(CHEMBL5205667)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed