Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with all data for entry = 50017151
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to human CDK2 (1 to 298 residues) expressed in Escherichia coli Tuner(DE3) assessed as dissociation constant by fluorescence spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  810nMAssay Description:Binding affinity to full-length human wild-type GSK-3-beta expressed in mammalian expression system assessed as dissociation constant by DiscoverX KI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to partial length human wild-type CDK13 expressed in mammalian expression system assessed as dissociation constant by DiscoverX KINO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to partial length human wild-type CDK12 expressed in mammalian expression system assessed as dissociation constant by DiscoverX KINO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to CDK12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to CDK13 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CDK5 (unknown origin) by kinase selectivity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of CDK3 (unknown origin) by kinase selectivity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600030(CHEMBL5171657)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated-histone H1 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600030(CHEMBL5171657)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated-histone H1 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50: 1.40nMAssay Description:Displacement of tracer 236 from recombinant human CDK8 incubated for 60 mins by TR-FRET based Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600028(CHEMBL5190816)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600028(CHEMBL5190816)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600030(CHEMBL5171657)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant CDK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated-histone H1 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM154576(K03861 (1))
Affinity DataIC50: 3nMAssay Description:Inhibition of NanoLuc-fused CDK8 (unknown origin) expressed in human HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600028(CHEMBL5190816)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600030(CHEMBL5171657)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant CDK9 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated-histone H1 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK6 (unknown origin) by kinase selectivity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600027(CHEMBL5202522)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9 (unknown origin) by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50526803(CHEMBL4434871 | US10870651, Compound 101)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK1 (unknown origin) expressed in baculovirus expression system using biotinylated peptide substrate incubated for 1 hr in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50526795(CHEMBL4450322)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Aurora A (unknown origin) using peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50526794(CHEMBL4303287 | US10787436, Compound I-18)
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK7 (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora B (unknown origin) using peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600029(CHEMBL8817)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged human CDK1 expressed in baculovirus expression system using histone H1 as substrate incubated for 45 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50600028(CHEMBL5190816)
Affinity DataIC50: 33nMAssay Description:Inhibition of N-terminal His-tagged human recombinant BRD4 BD1 (44 to 460 residues) expressed in Escherichia coli using acetylated-histone peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM8296(CHEMBL102714 | cid_176158 | 3-(2,4-dichlorophenyl)...)
Affinity DataIC50: 34nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 14(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50528810(CHEMBL4580787 | US12187701, Compound FMF-04-159-2)
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK14 (unknown origin) incubated for 6 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50526797(Ct-7001 | Ct7001 | ICEC-0942 | ICEC0942 | Samuraci...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CDK7 (unknown origin) using YSPTSPSYSPTSPSYSPTSPS peptide as substrate in presence of ATP by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50013510(CHEMBL3263773)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human CDK9 using ULight MBP peptide as substrate incubated for 1 hr in presence of ATP by TR-FRET based LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GSK-3-alpha (unknown origin) by kinase selectivity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 3(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataIC50: 58nMAssay Description:Inhibition of CDK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant CDK13 (unknown origin) expressed in baculovirus infected insect cells using Pol II CTD peptide as substrate in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant CDK13 (unknown origin) by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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