Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50017642
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603599(CHEMBL5187474)
Affinity DataIC50: 30nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 30nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603603(CHEMBL5190547)
Affinity DataIC50: 90nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LO in human leucocytes by measuring FLAP-dependent 5-LOproduct LTB4 in presence of calcium ionophore A23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603603(CHEMBL5190547)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant LTC4S expressed in HEK293 cell microsomal fraction preincubated for 10 mins followed by LTA4-methyl ester addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603599(CHEMBL5187474)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant LTC4S expressed in HEK293 cell microsomal fraction preincubated for 10 mins followed by LTA4-methyl ester addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603601(CHEMBL5180150)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603599(CHEMBL5187474)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as inhibition of FLAP-dependent 5-LO product LTB4 formation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603602(CHEMBL5208787)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603604(CHEMBL5181706)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603605(CHEMBL5193055)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603603(CHEMBL5190547)
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as inhibition of FLAP-dependent 5-LO product LTB4 formation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human recombinant LTC4S expressed in HEK293 cell microsomal fraction preincubated for 10 mins followed by LTA4-methyl ester addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant LTC4S (unknown origin) expressed in COS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as inhibition of FLAP-dependent 5-LO product LTB4 formation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed