Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50016435
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE8B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50594974(CHEMBL5186554)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to recombinant human PDE10A assessed as inhibition constant using fluorescein-labeled cAMP as substrate incubated for 5 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [3H]-cGMP from PDE9A2 (unknown origin) incubated for 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50390800(CHEMBL2070639)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human PDE7D4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM426313(US10513524, Compound (P3 | US11608342, Compound (P...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant human PDE9A1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM566472(US11419874, ND-7001 | 3-(8-methoxy-1- methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]-cAMP from recombinant PDE2 (unknown origin) expressed in African green monkey COS-7 cells incubated for 30 mins in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50457396(CHEMBL4206492)
Affinity DataIC50: 52nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM130503(US8822479, 37-1)
Affinity DataIC50: 55nMAssay Description:Displacement of [8-3H]-cGMP from recombinant mouse PDE9A expressed in baculovirus infected Sf9 insect cells incubated for 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 76nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50277784(N,N,2-trimethyl-5-nitrobenzenesulfonamide | CHEMBL...)
Affinity DataIC50: 90nMAssay Description:Displacement of [3H]-cAMP from recombinant human PDE7A1 incubated for 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50559697(Blx-028914 | Ht-0712 | IPL-455903 | OX-914)
Affinity DataIC50: 150nMAssay Description:Inhibition of full-length PDE4D3 (unknown origin) using FAM-cAMP as substrate incubated for 5 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM50034908((2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol | 3-(6-A...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50457394(CHEMBL4207515)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [3H]-cGMP from recombinant PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 incubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed