Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50015329
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells assessed as dissociation constant by surface plasmon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480978(US10906888, Example 196 | US10906888, Example 197 ...)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells assessed as dissociation constant by surface plasmon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480981(US10906888, Example 200 | US10906888, Example 199 ...)
Affinity DataKd:  37nMAssay Description:Binding affinity to recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells assessed as dissociation constant by surface plasmon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480924(US10906888, Example 138)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50585537(CHEMBL5084938)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480965(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrazin-2-yl)...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480929(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480917(7-oxa-2-azaspiro[3.5]non-2-yl(2-{[2-(pyrazin-2-yl)...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480956(US10906888, Example 173)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480931(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480971(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[1-(pyrimidin-5-y...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480918(US10906888, Example 132)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480917(7-oxa-2-azaspiro[3.5]non-2-yl(2-{[2-(pyrazin-2-yl)...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480919(US10906888, Example 133)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480931(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480933(US10906888, Example 147)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480934(US10906888, Example 149)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480917(7-oxa-2-azaspiro[3.5]non-2-yl(2-{[2-(pyrazin-2-yl)...)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480931(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480783(US10906888, Example 1)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480932(US10906888, Example 146)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480921(US10906888, Example 135)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394644(US10308615, Example 1 | 3-[(2-{[1-(pyrimidin-5-yl)...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM395107(US10308615, Example 118 | 3-({2-[(pyridin-3- ylmet...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394644(US10308615, Example 1 | 3-[(2-{[1-(pyrimidin-5-yl)...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480968(US10906888, Example 185)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480978(US10906888, Example 196 | US10906888, Example 197 ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50585535(CHEMBL5086259)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: 12nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetVanin 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Wistar han rat serum vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394644(US10308615, Example 1 | 3-[(2-{[1-(pyrimidin-5-yl)...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM395054(US10308615, Example 65 | 3-({2-[(1- phenylcyclopro...)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 25nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480990(US10906888, Example 150)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM395109(US10308615, Example 120 | 3-({2-[(pyrimidin- 5- yl...)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBiotinidase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480933(US10906888, Example 147)
Affinity DataIC50: 40nMAssay Description:Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480978(US10906888, Example 196 | US10906888, Example 197 ...)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells at 10 uM by 1H NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50585533(CHEMBL5094835)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394657(US10308615, Example 14 | (3-methylphenyl){2-[(pyri...)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 53nMAssay Description:Inhibition of mouse plasma vanin-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394679(US10308615, Example 34 | phenyl{2- [(pyridin-3- yl...)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM394672(US10308615, Example 27 | 3-{[2- (benzylamino) pyri...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM480928(8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells at 10 uM by 1H NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480981(US10906888, Example 200 | US10906888, Example 199 ...)
Affinity DataIC50: 122nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells at 10 uM by 1H NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM395089(US10308615, Example 100 | {2-[(pyridin-3- ylmethyl...)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
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