Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50016629
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596252(CHEMBL5190011)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596253(CHEMBL5203401)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM209918(US9273042, 7 | US9556135, 17)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596248(CHEMBL5194897)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50580216(VERUBECESTAT | Verubecestat | MK-8931 | SCH 900931...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596250(CHEMBL5204704)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596255(CHEMBL5195553)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596244(CHEMBL5208596)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596245(CHEMBL5195634)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596246(CHEMBL5203915)
Affinity DataIC50: 30nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596251(CHEMBL5197842)
Affinity DataIC50: 78nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596247(CHEMBL5170080)
Affinity DataIC50: 171nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50580216(VERUBECESTAT | Verubecestat | MK-8931 | SCH 900931...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596250(CHEMBL5204704)
Affinity DataIC50: 2.42E+3nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataIC50: 7.06E+3nMAssay Description:Inhibition of CAV1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM209918(US9273042, 7 | US9556135, 17)
Affinity DataIC50: 7.46E+3nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM209918(US9273042, 7 | US9556135, 17)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596244(CHEMBL5208596)
Affinity DataIC50: 1.47E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50: 1.59E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596253(CHEMBL5203401)
Affinity DataIC50: 2.31E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596251(CHEMBL5197842)
Affinity DataIC50: 2.42E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataIC50: 2.56E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596252(CHEMBL5190011)
Affinity DataIC50: 2.69E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596255(CHEMBL5195553)
Affinity DataIC50: 3.89E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of human ERG expressed in HEK cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataIC50: 4.82E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596248(CHEMBL5194897)
Affinity DataIC50: 5.42E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596245(CHEMBL5195634)
Affinity DataIC50: 5.52E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596247(CHEMBL5170080)
Affinity DataIC50: 6.00E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596246(CHEMBL5203915)
Affinity DataIC50: 6.00E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596254(CHEMBL5198665)
Affinity DataKi:  1nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596252(CHEMBL5190011)
Affinity DataKi:  1nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596248(CHEMBL5194897)
Affinity DataKi:  2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596253(CHEMBL5203401)
Affinity DataKi:  2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50580216(VERUBECESTAT | Verubecestat | MK-8931 | SCH 900931...)
Affinity DataKi:  2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM209918(US9273042, 7 | US9556135, 17)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596255(CHEMBL5195553)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596246(CHEMBL5203915)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596250(CHEMBL5204704)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596245(CHEMBL5195634)
Affinity DataKi:  4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataKi:  4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596244(CHEMBL5208596)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596251(CHEMBL5197842)
Affinity DataKi:  10nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596247(CHEMBL5170080)
Affinity DataKi:  12nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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