Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50016857
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597817(CHEMBL5192406)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597812(CHEMBL5192215)
Affinity DataIC50: 3nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50597817(CHEMBL5192406)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated with compound for 20 mins followed by substrate addition measured after 120 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597813(CHEMBL5183804)
Affinity DataIC50: 13nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597807(CHEMBL5190688)
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548269((R)-2-((R)-3-methylmorpholino)-6-(trifluoromethyl)...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548239((R)-7-(tert-butyl)-2-((R)-3-methylmorpholino)-6,7-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597814(CHEMBL5200373)
Affinity DataIC50: 48nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597809(CHEMBL5181274)
Affinity DataIC50: 53nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548235((R)-7-isopropyl-2-((R)-3-methylmorpholino)-6,7-dih...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548243((5aS,8aR)-2-((R)-3-methylmorpholino)-5,5a,6,7,8,8a...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548265((R)-7'-cyclopropyl-2'-((R)-3-methylmorpholino)-7'H...)
Affinity DataIC50: 84nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548251((S)-2-((R)-3-methylmorpholino)-7-(trifluoromethyl)...)
Affinity DataIC50: 92nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597818(CHEMBL5197817)
Affinity DataIC50: 130nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597811(CHEMBL5195258)
Affinity DataIC50: 130nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548247((S)-7-(2-hydroxypropan-2-yl)-2-((R)-3-methylmorpho...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548253((6S,7R)-7-cyclopropyl-6-methyl-2-((R)-3-methylmorp...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548237((R)-7-cyclobutyl-2-((R)-3-methylmorpholino)-6,7-di...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597816(CHEMBL5202968)
Affinity DataIC50: 240nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597808(CHEMBL5190274)
Affinity DataIC50: 320nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50597818(CHEMBL5197817)
Affinity DataIC50: 330nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated with compound for 20 mins followed by substrate addition measured after 120 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548241((R)-7-cyclopentyl-2-((R)-3-methylmorpholino)-6,7-d...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597810(CHEMBL5204287)
Affinity DataIC50: 470nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548271((6S,7R)-6,7-dicyclopropyl-2-((R)-3-methylmorpholin...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM50597815(CHEMBL5182171)
Affinity DataIC50: 710nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Pharmaron Beijing

Curated by ChEMBL
LigandPNGBDBM548273((R)-7-cyclopropyl-6,6-dimethyl-2-((R)-3-methylmorp...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed