Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50016856
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597805(CHEMBL5199007)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597805(CHEMBL5199007)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597802(CHEMBL5205044)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorimetric substrate incubated for 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597804(CHEMBL5201623)
Affinity DataIC50: 24nMAssay Description:Inhibition of HDAC6 derived from human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 25nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorimetric substrate incubated for 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 60nMAssay Description:Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST-tagged human NCOR2 (395 to 489 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597804(CHEMBL5201623)
Affinity DataIC50: 82nMAssay Description:Inhibition of HDAC1 derived from human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597803(CHEMBL5180137)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human HDAC1 using fluorogenic acetylated peptide substrate incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50: 800nMAssay Description:Inhibition of C-terminal 6xHis-tagged full-length recombinant human HDAC2 (1 to 488 residues) expressed in Sf9 insect cells by Luminescence Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597806(CHEMBL5195956)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of recombinant human HDAC1 using fluorescent deacetylated substrate incubated for 15 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50597806(CHEMBL5195956)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant human HDAC2 using fluorescent green substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed